[ English | Bahasa Malaysia ] Hari ini ialah 29 Oct 2020, 10:08 AM (Terakhir dikemaskini pada: 22nd Oct 2020)

Text Red Text Black Text Blue Text Green Text Smaller Text Reset Text Larger

Publication Details
Year :

2011

Journal :

Adiratna Mat Ripen, Takeshi Nitta, Shigeo Murata, Keiji Tanaka and Yousuke Takahama (2011). Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit B5t. European Journal of Immunology 41(5): 1278-1287

Abstract :

Proteasomes are responsible for generating peptides presented by class I MHC molecules of the immune system. ?5t, a recently identified proteasome component, is specifically expressed in thymic cortical epithelial cells (cTECs) and plays a pivotal role in generating an immunocompetent repertoire of class I MHC-restricted CD8(+) T cells. Here, we report that ?5t is detectable in the thymus as early as E12.5 mouse embryos. We also found that ?5t expression in cTECs was detectable in mice deficient for RelB or Rag2, indicating that ?5t in cTECs is expressed in the absence of thymic medulla formation or thymocyte development beyond the CD4(-) CD8(-) stage. ?5t expression in the embryonic thymus was not detectable in Foxn1-deficient nude mice, although its expression was not reduced in mice deficient for both CCR7 and CCR9, in which fetal thymus colonization by leukocytes is defective. These results indicate that ?5t expression in cTECs is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation.

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

Notis

Logo-SIRIM-n-UKAS-IMR

IMR ialah sebuah organisasi bertauliah oleh SIRIM (nombor sijil 2972).

Laman ini sesuai dilihat menggunakan Firefox (24.0) dengan resolusi 1280 x 768 pixels atau lebih.

Lokasi Kami

world

Kami terletak di Jalan Pahang, 50588 Kuala Lumpur, Malaysia. Kami beroperasi dari jam 8.00pg - 5.00ptg Isnin - Jumaat. Klik pada imej peta untuk melancarkan servis Google Maps.

Hubungi Kami