[ English | Bahasa Malaysia ] Hari ini ialah 22 Oct 2019, 01:38 PM (Terakhir dikemaskini pada: 22nd Oct 2019)

Text Red Text Black Text Blue Text Green Text Smaller Text Reset Text Larger

Pengenalan kepada Unit Imunogenetik

. Terakhir dikemaskini: 18 Mac 2014Jumlah paparan: 12050

{autotoc}

Pengenalan

Imunogenetik adalah kajian mengenai hubungan di antara genetik dan sistem imun. Kedua-dua sistem ini merupakan sistem yang kompleks serta canggih dan interaksi di antara keduanya menimbulkan beberapa persoalan kajian yang mencabar. Unit Imunogenetik menjalankan penyelidikan dan menyediakan perkhidmatan diagnostik khusus untuk program transplan di seluruh negara melalui penjenisan tisu HLA. Makmal ini ditubuhkan pada tahun 1985 dan memberi khidmat sokongan bagi kedua-dua jenis tranplan iaitu sum-sum tulang dan organ. Penjenisan tisu HLA yang bukan bertujuan untuk pemindahan turut disediakan seperti kajian berkaitan dengan penyakit (disease association studies). Kesemua penjenisan tisu HLA dilakukan menggunakan teknik molekular. Unit Immunogenetik juga menyelia dan bekerjasama rapat dengan Malaysian Marrow Donor Registry (MMDR) yang kini bertukar nama kepada Malaysian Stem Cell Registry Malaysia (MSCR). Bagi penderma MSCR, kami menguji kedua-dua jenis penderma iaitu yang mempunyai pertalian darah dan yang tidak serta transplan dari darah tali pusat. Unit Immunogenetik terlibat dalam menyediakan latihan untuk petugas profesional kesihatan yang terlibat dalam bidang transplan.

Objektif/ Teras Penyelidikan

Unit Immunogenetik menyediakan:

  • Perkhidmatan ujian sebelum transplan bagi sum-sum tulang dan organ untuk pengesahan keserasian.
  • Perkhidmatan ujian selepas transplan bagi organ.
  • Ujian bagi pesakit yang akan keluar negara ataupun adik-beradik bagi pesakit yang berada di luar negara.
  • Ujian untuk penyakit yang berkaitrapat dengan alel HLA serta memberikan kesan buruk ke atas pesakit.Our research focuses on disease associations and population genetics.

Penyelidikan yang dijalankan memberi tumpuan kepada bidang genetik yang berhubungkait dengan penyakit-penyakit dan genetik populasi.

Kami mengenalpasti dan menentukan frekuensi alel dalam penduduk tempatan serta yang berhubungkait dengan penyakit seperti 'aplastic anemia', 'rheumatoid arthritis' dan 'ankylosing spondylitis'.

Perkhidmatan

  1. Penjenisan tisu HLA Kelas I
  2. Penjenisan tisu HLA Kelas II
  3. HLA-B*27, -B*5, -B*12, -B*1502, -B*5701
  4. HLA Crossmatch
  5. Ujian antibodi HLA- saringan kelas I
  6. Ujian antibodi HLA- saringan kelas II
  7. Pengesanan antibodi HLA-antibodi spesifik

Senarai kakitangan

Information on testing may be obtained by contacting:

  • Puan Maiselamah Lisut
  • Puan Lee Yin Yin
  • Puan Rozinah Mohamed

Pembentangan & Penerbitan AIRC Tahun 2011

Bil

Title

1

Zailatul Hani Mohamad Yadzir, Rosmilah Misnan, Noormalin Abdullah, Masita Arip, Shahnaz Murad Identification of Major Allergens of Wildflower Honey. (2011) Southeast Asian Journal of Tropical Medicine and Public Health 42(2): 370-75

2

 

Choong-Chor Chang, Chun-Lai Too, Shahnaz Murad,

and Suraiya Hani Hussein

Association of HLA-B*1502 allele with carbamazepine induced toxic epidermal necrolysis and Stevens–Johnson syndrome in the multi-ethnic Malaysian population. 2011. International Journal of Dermatology, 50, 221–224

3

Too Chun-Lai, Leonid Padyukov, Jasbir Singh Dhaliwal, Emeli Lundstrom, Abqariyah Yahya, Nor Asiah Muhamad, Lars Klareskog, Lars Alfredsson, Per Tobias Larsson, Shahnaz Murad, for the Malaysian epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Study Group

Shared Epitope Alleles Remain A Risk Factor for Anti-Citrullinated Proteins Antibody (ACPA) –  Positive Rheumatoid Arthritis in Three Asian Ethnic Groups PLOS One June 2011 Volume 6  Issue 6 e21069

4

JS Dhaliwal, M Shahnaz, A Azrena, Irda YA, Salawati M, CL Too, and Lee YY Gene frequencies of HLA-A, -B and –DR alleles in 3 indigenous populations of Sabah and Sarawak. Tissue Antigens 75:166-169(2011)

5

Adiratna Mat Ripen1,2, Takeshi Nitta1, Shigeo Murata3, Keiji Tanaka4, Yousuke Takahama1,*Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t. European Journal of Immunology 411, 278–1287, May 2011

6

JS Dhaliwal, Lily Wong, Muhammad Amir Kamaluddin, Lee Yin Yin and Shahnaz Murad.  Susceptibility to Aplastic Anaemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia. Human Immunology (in press) 2011

7

Uma Devi Palanisamy, Muniswaran Sivanathan, Ammu Kutty Radhakrishnan, Nagaraja Haleagrahara, Thavamanithevi Subramaniam and Gan Seng Chiew. An Effective Ostrich Oil Bleaching Technique Using Peroxide Value as an Indicator. Molecules 2011, 16, 5709-5719

 

Presentations 2011

 

Bil

Title

Presenter

Date & Venue

1.

Identification of the Major Allergens of Macrobrachium rosenbergii (Giant Freshwater Prawn) by Two-Dimensional Electrophoresis and Mass Spectrometry

Zailatul Hani Mohamad Yadzir

11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

2.

Detection of autoantibodies (anti-gliadin, anti-tissue transglutaminase and anti-endomysium) in diagnosis of celiac disease- A preliminary report.

Dr Ainur Yusniza Yusof

11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

3.

Detection of Antiphospholipid Antibodies In Female With Fetal Loss

Ching Yee Ming

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

4.

High Resolution DNA Typing of HLA-A, -B & -DRB1 Loci by PCR-SSOP-Luminex in Malay Population

Norfarhana Khairul Fahmy

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

5.

Detection of Neuronal Autoantibodies (Anti-Hu, Anti-Ri, Anti-Yo, Anti-Ma  and Anti-Amphiphysin) in patients with Paraneoplastic Neurological Syndrome (PNS)

Dr Masita Arip

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

6.

Allergy to Paracetamol: Two Cases of Successful Rapid Desensitization with Paracetamol

Dr. Noormalin Abdullah

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

7

A Retrospective Study of Frequency of Autoantibodies (Anti -Islet Cells (ICA), Anti-Glutamic Acid Decarboxylase (GAD), Insulin Autoantibodies (IAA) and Anti-Tyrosine Phosphatase (IA2) ) In Type 1 Diabetes 

Dr Norhazlin Mustafa

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

8

Defining B cell defects in Primary Immunodeficiency patients in Malaysia (Tajuk pembentangan lisan: Analysis of Bruton’s Tyrosine Kinase (BTK) expression in Monocytes by Flow Cytometry)

Chear Chai Teng

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

9

Wiskott-Aldrich protein expression in a child with X linked thrombocytopenia

Dr Gill HK

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

10

“Identification Of Bruton’s Tyrosine Kinase Gene (Btk) Mutation In A Malaysian Family with X-Linked Agammaglobulinemia”

Chear CT

9 - 10 June 2011, Armada Hotel, Petaling Jaya Rare Disorder & Genetics Conference 2011

11

Evaluation of Saliva As A Source of DNA for Human Leukocyte Antigen (HLA) – A Pilot Study

Dr Masita Arip

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

12

Distribution of HLA-A, -B & -DRB1 Alleles Among the Malay Population in Malaysian Marrow Donor Registry (MMDR)

Norfarhana Khairul Fahmy

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

13

HLA-A, -B & -DR Alleles Frequencies in Chinese Population: A Malaysian Marrow Donor Registry Experience

Dr Norhazlin Mustafa

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

14

HLA-A, -B and –DR Alleles and frequencies among Indians in Malaysian Marrow Donor Registry

Salawati Mansor

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

Soalan Lazim (item berkemungkinan untuk dimasukkan)

  1. Apakah HLA?
  2. Mengapa pesakit perlu menjalani ujian HLA?
  3. Bagaimanakah Jenis HLA seseorang ditentukan?
  4. Bagaimana HLA menaip dijalankan?
  5. Apakah antibodi?
  6. Apakah silang padan?
  7. Apakah PRA?
  8. Apa yang menyebabkan antibodi anti-HLA berkembang?
  9. Bolehkah anti-HLA antibodi berubah?
  10. Mengapa ia boleh jadi sukar untuk mencari penderma HLA-dipadankan?
  11. Apakah Immunogenetik?

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

Notis

Logo-SIRIM-n-UKAS-IMR

IMR ialah sebuah organisasi bertauliah oleh SIRIM (nombor sijil 2972).

Laman ini sesuai dilihat menggunakan Firefox (24.0) dengan resolusi 1280 x 768 pixels atau lebih.

Lokasi Kami

world

Kami terletak di Jalan Pahang, 50588 Kuala Lumpur, Malaysia. Kami beroperasi dari jam 8.00pg - 5.00ptg Isnin - Jumaat. Klik pada imej peta untuk melancarkan servis Google Maps.

Hubungi Kami