Vui King Vincent-Chong, Lee Peng Karen-Ng, Zainal Ariff Abdul Rahman, Yi-Hsin Yang, Arif Anwar, Zubaidah Zakaria, Padmaja Jayaprasad Pradeep, Thomas George Kallarakkal, Keng Kiong Tay, Mannil Thomas Abraham, Siti Mazlipah Ismail and Rosnah Binti Zain (2014). Distinct pattern of chromosomal alterations and pathways in tongue and cheek squamous cell carcinoma. Head & Neck 36(9): 1268-1278
Background. The purpose of this study was to investigate the cause of behavioral difference between tongue and cheek squamous cell carcinomas (SCCs) by verifying the copy number alterations (CNAs).
Methods. Array comparative genomic hybridization (aCGH) was used to profile unique deletions and amplifications that are involved with tongue and cheek SCC, respectively. This was followed by pathway analysis relating to CNA genes from both sites.
Results. The most frequently amplified regions in tongue SCC were 4p16.3, 11q13.4, and 13q34; whereas the most frequently deleted region was 19p12. For cheek SCC, the most frequently amplified region was identified on chromosome 9p24.1-9p23; whereas the most common deleted region was located on chromosome 8p23.1. Further analysis revealed that the most significant unique pathway related to tongue and cheek SCCs was the cytoskeleton remodeling and immune response effect on the macrophage differentiation pathway.
Conclusion. This study has showed the different genetic profiles and biological pathways between tongue and cheek SCCs.