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Objectives of Toxicology & Pharmacology Unit

. Last Updated: 15 December 2011Hits: 13032

Objectives

  • To strengthen the research of plant extracts for pre-clinical studies to determine the toxicological and pharmacological effects
  • To ascertain the safety and efficacy of extracts on the different types of animal models
 
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Specific Objectives 

  • To strengthen techniques for toxicity testing


General Toxicology

  • Acute, sub-acute and chronic toxicity testing
  • Histopathology testing
  • Hematological testing
  • Biochemistry testing


Genotoxicity

  • Cytotoxicity test using a few methods e.g. Viability method or metabolic activity
  • Mutagenicity test: MLA, AMES test, COMET Assay, In- vivo and in- vitro micronucleus test
  • Biochemical Toxicology
  • Hepatotoxicity - Liver enzymes analysis, cytochrome P450


Product Safety

  • Adulterant (steroid and other drugs)
  • Contaminants (heavy metals, bacterial, pesticides)
  • To develop techniques for developmental toxicology including teratogenicity and reproductive toxicology
  • To established methods, facilities for pharmacological investigations of herbal products; including (ADME) - Administration e.g. Absorption, Distribution ; look for target organ, Metabolism e.g. Excretion: duration of drug from entry to exit.
  • To establish the pharmacodynamics of herbal products: to look at the mechanism of action of the herbal products
  • To develop and strengthen technique for Biochemical toxicology : for other specific organ toxicity


Future Plans

  • To set-up the High Throughput screening for Toxicity
  • To establish High Throughput screening for pharmacological testing
  • Pharmaco-toxicology profiling of biomolecules from Natural Resources to Drug Development in order to prepare the products for clinical trials (Phase I, II, and III)

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

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