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Activities of Diabetes & Endocrine Unit

. Last Updated: 12 July 2016Hits: 16960

RESEARCH

My Body is Fit and Fabulous: an intervention programme to combat obesity among Malaysian school children (MyBFF@school) – Phase II
MyBFF@school is an interventional programme introduced as a curriculum activity in selected primary and secondary schools in Wilayah Persekutuan, Selangor and Negeri Sembilan, specific for overweight and obese students. It is a collaborative effort between the Ministry of Health Malaysia, Ministry of Education and University of Malaya to combat childhood obesity. MyBFF@school consists of three components (physical activity, nutritional and psychological modules) and is implemented together as a package. The primary objective of MyBFF@school is to evaluate the effectiveness of the programme in reducing BMI and body fat of overweight and obese children and to keep them motivated to be fit and healthy. Biochemical tests such as blood glucose levels, insulin resistance, HbA1c, lipid profiles, liver enzymes, obesity-related hormones and cytokines are carried out at baseline, at 6-months and 12-months during the study period.
(Fazliana M, Nur Zati Iwani AK, Ruziana Mona WMZ)

My Body is Fit and Fabulous: an intervention programme to combat obesity among housewives in the Klang Valley (MyBFF@home)
The goal of this study is to evaluate the effectiveness of the intervention package in reducing body weight among overweight and obese housewives in the Klang Valley. The aim is to determine the changes in blood cardiometabolic profiles (blood glucose levels, lipid profiles, HbA1C, insulin resistance) and body composition (fat mass, body fat percentage, visceral fat area, skeletal muscle mass among housewives (pre- and post- intervention). This project is in collaboration with the Institute of Public Health.
(Fazliana M, Liyana AZ, Fatin S)

Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model
Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. Anti-diabetic effects of two traditional plants, known as Tinospora crispa and Gynostemma pentaphyllum were studied in diabetic rats and the mechanism of insulin release from the islets involved was identified. The effects of Gynostemma pentaphyllum extract on innate immune mechanisms in the urinary tract were also investigated both in vivo and in vitro studies.
(Ezarul Faradianna L)

Searching for new biomarkers of diabetic nephropathy in Malaysians with type 2 Diabetes
Despite the current markers that have been used in the clinic, the development of more sensitive treatment strategies for diabetic nephropathy (DN) could assist successful therapeutic interventions at the early stage. Type 2 Diabetes (T2D) and DN are complex diseases, which involve interactions between genetic and environmental factors. Four candidates' genes were analysed in 1142 Malaysians with Normal Glucose Tolerance (NGT), T2D and DN. Results from genetic and zebra-fish studies have provided evidence suggesting solute carrier family 12 (sodium/chloride transporters) member 3 (SLC12A3) may potentially be a new biomarker for DN. Data from genetic and protein analyses showed that intercellular adhesion molecule 1 (ICAM-1) K469E9A/G polymorphism and plasma pentraxin 3 (PTX3) were significantly associated with DN. The epigenetic study using pyrosequencing technology indicated that increased DNA methylation levels of solute carrier family 30 member 8 (SLC30A8) gene were associated with T2D but not DN.
(Norhashimah AS)

Gene expression profiles associated with hepatoxicity in pregnant rat treated with Ubi Gadong (Dioscorea hispida) extract
This is a collaboration project between the CDNRC Diabetes and Metabolic Disorder Unit and the HMRC Toxicology and Phytochemistry Units of the IMR. In this project, the identification of steroidal saponins from Dioscorea hispida was determined by UHPLC/MS. This technique provides the structural characterisation from accurate mass measurement for MS and MS-MS experiments. This study was carried out to identify the toxicity effects of different concentrations of Dioscorea hispida on liver and to identify the gene expression profiles in pregnant rats using PCR array analysis technique. This information was then used to determine which metabolic and signal transduction pathways were affected following the mechanisms of action involved.
(Ezarul Faradianna Lokman)

Detection of microsatellite marker in polycystic ovary syndrome
Microsatellites are commonly used as genetic markers. Thus their detection and analysis constitutes a very important tool for the mapping of genetic diseases. Microsatellite marker D19S884 has been associated with PolyCystic Ovary Syndrome (PCOS), the most common reproductive endocrinopathy of women in their childbearing years and is responsible for an estimated 70% of cases of anovulatory infertility. In this study, we detect microsatellites extracted from blood DNA of women with PCOS. DNA microsatellites are amplified by Polymerase Chain Reaction (PCR). Alleles are separated on low-melting agarose gels and analysed using fragment analysis. Early results suggest that the most common allele in the Malaysian population is A9.
(Fazliana M, Liyana AZ, Fatin S)

DIAGNOSTICS

Tests offered at the IMR and the related workload is shown below:

No

Name of tests

No. of tests offered

Workload: No. of specimens received

Workload: No. of tests performed

2014

2015

2014

2015

2014

2015

1.

INTACT PARATHYROID HORMONE (iPTH)

No limit

No limit

14,777

15,901

14,729

15,720

2.

TESTOSTERONE

No limit

No limit

175

51

173

51

3.

DHEADROEPIANDROSTENEDIONE (DHEAS)

No limit

No limit

181

185

180

185

4.

GROWTH HORMONE

No limit

No limit

497

563

495

554

5.

INSULIN-LIKE GROWTH FACTOR 1

No limit

No limit

1,770

1,988

1,763

1,976

6.

THYROGLOBULIN

No limit

No limit

3,777

4,067

3,770

4,052

7.

17-OH PROGESTERONE

No limit

No limit

954

1,012

954

1,002

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

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