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Introduction to Immunogenetics Unit

. Last Updated: 25 January 2012Hits: 19276

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Introduction

Immunogenetics is the study of the relationship between genetics and the immune system. The complexity and sophistication of both these systems and their interaction give rise to a number of challenging research questions.  The Immunogenetics Unit conducts research and provides specialized diagnostic services for transplantation programs nationwide. The laboratory was setup in 1985 and we support both the bone marrow and solid organ transplantation. HLA typing is also provided for non-transplant purposes. All typing is performed using molecular techniques. The Immunogenetics Unit also oversees and works closely with the Malaysian Marrow Donor Registry (MMDR) now renamed the Malaysian Stem Cell Registry (MSCR). We test both for related and unrelated donors from the MSCR as well as for cord blood transplants. The Immunogenetics Unit is involved in training health care professionals in transplantation

Objective(s) /Research thrust(s)

The Immunogenetics Unit provides:

  • pre transplant testing services for bone marrow and solid organ transplants to determine compatibility
  • post transplant services for solid organ transplants
  • testing for patients going overseas or for siblings of patients who are overseas
  • testing for diseases associated with HLA alleles as well as HLA alleles associated with adverse outcomes in patients

Our research focuses on disease associations and population genetics. We are identifying and determining the frequency of the alleles found in local populations as well as disease associations with aplastic anemia, rheumatoid arthritis and ankylosing spondylitis.

Services

1

Class I HLA typing

2

Class II HLA typing

3

HLA B27, B5, B12, B1502, B5701

4

HLA crossmatching

5

HLA antibody detection - Specific antibody

6

HLA antibody detection - Screening Class I

7

HLA antibody detection - Screening Class II

List of personnel

Information on testing may be obtained by contacting:

  • Ms Maiselamah Lisut
  • Ms Lee Yin Yin
  • Ms Rozinah Mohamed

Presentation(s) & Publication(s) 2011 for AIRC

Bil

Title

1

Zailatul Hani Mohamad Yadzir, Rosmilah Misnan, Noormalin Abdullah, Masita Arip, Shahnaz Murad Identification of Major Allergens of Wildflower Honey. (2011) Southeast Asian Journal of Tropical Medicine and Public Health 42(2): 370-75

2

 

Choong-Chor Chang, Chun-Lai Too, Shahnaz Murad,

and Suraiya Hani Hussein

Association of HLA-B*1502 allele with carbamazepine induced toxic epidermal necrolysis and Stevens–Johnson syndrome in the multi-ethnic Malaysian population. 2011. International Journal of Dermatology, 50, 221–224

3

Too Chun-Lai, Leonid Padyukov, Jasbir Singh Dhaliwal, Emeli Lundstrom, Abqariyah Yahya, Nor Asiah Muhamad, Lars Klareskog, Lars Alfredsson, Per Tobias Larsson, Shahnaz Murad, for the Malaysian epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Study Group

Shared Epitope Alleles Remain A Risk Factor for Anti-Citrullinated Proteins Antibody (ACPA) –  Positive Rheumatoid Arthritis in Three Asian Ethnic Groups PLOS One June 2011 Volume 6  Issue 6 e21069

4

JS Dhaliwal, M Shahnaz, A Azrena, Irda YA, Salawati M, CL Too, and Lee YY Gene frequencies of HLA-A, -B and –DR alleles in 3 indigenous populations of Sabah and Sarawak. Tissue Antigens 75:166-169(2011)

5

Adiratna Mat Ripen1,2, Takeshi Nitta1, Shigeo Murata3, Keiji Tanaka4, Yousuke Takahama1,*Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t. European Journal of Immunology 411, 278–1287, May 2011

6

JS Dhaliwal, Lily Wong, Muhammad Amir Kamaluddin, Lee Yin Yin and Shahnaz Murad.  Susceptibility to Aplastic Anaemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia. Human Immunology (in press) 2011

7

Uma Devi Palanisamy, Muniswaran Sivanathan, Ammu Kutty Radhakrishnan, Nagaraja Haleagrahara, Thavamanithevi Subramaniam and Gan Seng Chiew. An Effective Ostrich Oil Bleaching Technique Using Peroxide Value as an Indicator. Molecules 2011, 16, 5709-5719

 

Presentations 2011

 

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Title

Presenter

Date & Venue

1.

Identification of the Major Allergens of Macrobrachium rosenbergii (Giant Freshwater Prawn) by Two-Dimensional Electrophoresis and Mass Spectrometry

Zailatul Hani Mohamad Yadzir

11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

2.

Detection of autoantibodies (anti-gliadin, anti-tissue transglutaminase and anti-endomysium) in diagnosis of celiac disease- A preliminary report.

Dr Ainur Yusniza Yusof

11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

3.

Detection of Antiphospholipid Antibodies In Female With Fetal Loss

Ching Yee Ming

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

4.

High Resolution DNA Typing of HLA-A, -B & -DRB1 Loci by PCR-SSOP-Luminex in Malay Population

Norfarhana Khairul Fahmy

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

5.

Detection of Neuronal Autoantibodies (Anti-Hu, Anti-Ri, Anti-Yo, Anti-Ma  and Anti-Amphiphysin) in patients with Paraneoplastic Neurological Syndrome (PNS)

Dr Masita Arip

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

6.

Allergy to Paracetamol: Two Cases of Successful Rapid Desensitization with Paracetamol

Dr. Noormalin Abdullah

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

7

A Retrospective Study of Frequency of Autoantibodies (Anti -Islet Cells (ICA), Anti-Glutamic Acid Decarboxylase (GAD), Insulin Autoantibodies (IAA) and Anti-Tyrosine Phosphatase (IA2) ) In Type 1 Diabetes 

Dr Norhazlin Mustafa

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

8

Defining B cell defects in Primary Immunodeficiency patients in Malaysia (Tajuk pembentangan lisan: Analysis of Bruton’s Tyrosine Kinase (BTK) expression in Monocytes by Flow Cytometry)

Chear Chai Teng

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

9

Wiskott-Aldrich protein expression in a child with X linked thrombocytopenia

Dr Gill HK

11-13th March 2011,

12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur

10

“Identification Of Bruton’s Tyrosine Kinase Gene (Btk) Mutation In A Malaysian Family with X-Linked Agammaglobulinemia”

Chear CT

9 - 10 June 2011, Armada Hotel, Petaling Jaya Rare Disorder & Genetics Conference 2011

11

Evaluation of Saliva As A Source of DNA for Human Leukocyte Antigen (HLA) – A Pilot Study

Dr Masita Arip

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

12

Distribution of HLA-A, -B & -DRB1 Alleles Among the Malay Population in Malaysian Marrow Donor Registry (MMDR)

Norfarhana Khairul Fahmy

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

13

HLA-A, -B & -DR Alleles Frequencies in Chinese Population: A Malaysian Marrow Donor Registry Experience

Dr Norhazlin Mustafa

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

14

HLA-A, -B and –DR Alleles and frequencies among Indians in Malaysian Marrow Donor Registry

Salawati Mansor

18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi

10th Annual Scientific Meeting, College of Pathologists AMM

FAQ (possible items to be included)

  1. What is HLA?
  2. Why would a patient need HLA testing?
  3. How is a person’s HLA type determined?
  4. How is HLA typing performed?
  5. What is an antibody?
  6. What is a cross match?
  7. What is PRA?
  8. What causes anti-HLA antibodies to develop?
  9. Can anti-HLA antibodies change?
  10. Why can it be so difficult to find an HLA-matched donor?
  11. What is immunogenetics?

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

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