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Publication Details
Year :

2013

Journal :

Zati Iwani AK, Ruziana Mona WZ, Nor Idayu R and Wan Nazaimoon WM (2013). The Usefulness of Cystatin C as a Markers for Chronic Kidney Disease. Universal Journal of Clinical Medicine 1(2): 28-33

Abstract :

Background : Diagnostic marker to detect chronic kidney disease (CKD) at early stage is important as early intervention can slow the loss of kidney function. Plasma or serum Cystatin C (CysC) is said to be a superior marker for CKD compared to serum creatinine (SCr) to detect mild GFR reduction between 60 and 90 ml/min/1.73m2 . Methods: We analysed blood and urine samples from 418 normal subjects and 37 Type 2 diabetes patients (T2DM) with CKD. Estimation of glomerular filtration rate (eGFR) was determined using CKD-EPI. We compared the level CysC by CKD staging. Then, the correlation CysC and eGFR were compared between the normal subjects and the T2DM patients.Results : Plasma CysC level increase with the progression of CKD and was significantly elevated in CKD stage 2. CysC levels were highly correlated with eGFR in the T2DM patients. Conclusion: These results indicated that CysC have the potential of detecting early CKD especially in those with high risk such as the T2DM patients and also hypertension.

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

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