[ English | Bahasa Malaysia ] Today is 20th Sep 2021, 01:57 PM (Last updated: 20th Sep 2021)

Text Red Text Black Text Blue Text Green Text Smaller Text Reset Text Larger

Publication Details
Year :

2012

Journal :

Saraswathy TS, AS Santhana Raj, O Khairul Azuan, R Aida Suhana, A Izan Shahrina and S Zainah (2012). Electron microscopy studies of human adenovirus isolated from an acute respiratory disease outbreak in a Police Training Centre in Kuala Lumpur, Malaysia. Annals of Microscopy 12: 20-26

Abstract :

An outbreak of acute respiratory disease occurred in a Police Training Centre in March 2011 in Kuala Lumpur, Malaysia. The outbreak resulted in the hospitalization of more than 100 police trainees; 5 of these trainees needed intensive care treatment, however, 3 succumbed to the infection. Samples from the hospitalised cases and post mortem samples from the fatal cases were analysed by polymerase chain reaction assay. Adenovirus was identifi ed in all these cases and sequencing analysis of the partial hexon gene revealed that human adenovirus type 7 belonging to the B2 species was the aetiological agent responsible for the outbreak. Positive Human embryonic cell (Hel) cultures showing cytopathological effects were also processed for thin section electron microscopy. Transmission electron microscopy observations showed non-enveloped virus particles with icosahedral capsids, about 80 nm in size, scattered in the infected cell. Virus assembly in the nucleus were seen as paracrystalline arrays which were typical of adenovirus replication. In our study, electron microscopy was a useful diagnostic tool which provided a visual confi rmation of the aetiological agent in the disease outbreak.

myGOV MAMPU JPA IKU MSC NMMR CRC MyHEALTH MOH Globinmed SPA krste.my

Notice

Logo-SIRIM-n-UKAS-IMR

IMR is a SIRIM accredited organisation (certificate number 2972).

This site is best viewed on Firefox (24.0) with resolution higher than 1280 x 768 pixels.

Our Location

world

Located at Jalan Pahang, 50588 Kuala Lumpur, Malaysia. We operate from 8.00am - 5.00pm Monday - Friday. Click on the map image to launch Google Maps service.

Get in touch with us