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Molecular Pathology Unit

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RESEARCH 

| 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 |

 

Year 2008

GnRH and cancer (Teng LH, Munirah A, Soga T, Ogawa S, Ishwar P, Khoo ASB)

Establishment of model systems to study NPC and studies on the role of EBV genes in NPC (Munirah A, Daker M, Roslina H, Chu TL, Khairul MM, Tan SK, Hoe SLL, Siti Rohana P, Kam PV, Busson P, Takada K, Khoo ASB)

Nasopharyngeal specific genes and their promoters (Yee G, Munirah A, Chu TL, Khoo ASB)

Wnt signaling in Nasopharyngeal Carcinoma (NPC) (Munirah A, Roslinda AS, Siti Rohana P, Chu TL, Tan SK, Zabidi MM, Yap LF, Teo SH, Khoo ASB)

Alterations of p53 and RB2/p130 genes in Malaysiannasopharyngeal carcinoma samples (Hoe SLL, ES Lee, Khoo ASB, SC Peh)

Mutational studies on 21-hydroxylase deficient patients diagnosed with Congenital Adrenal Hyperplasia (CAH) (Pauline B, Lim PG, Huraizah S, Choy YS, Wu LL, Khoo ASB)

External collaborative projects (Khoo ASB)

A multi institutional study on the Clinical Outcome of patients with nasopharyngeal carcinoma (NPC) (Pua KC, Khoo ASB, The Malaysian Nasopharyngeal Carcinoma Study Group)

Development of a NPC-specific peptide vaccine therapy as a neoadjuvant therapy for nasopharyngeal cancer (Collaborative project with Dr. Teo Soo Hwang Cancer Research Initiatives Foundation (CARIF) within the NPC Research Program (Khoo ASB))

Association study of selected candidate genes and NPC susceptibility (Collaborative Project with Dr. Ng Ching Ching, Institute of Biological Sciences, University of Malaya within the NPC Research Program (Khoo ASB))

Serum expression proteomics of patients with nasopharyngeal carcinoma (Collaborative Project with Prof. Dr. Onn Haji Hashim, Dept. of Molecular Medicine, University of Malaya Medical Centre within the NPC Research Program (Khoo ASB))

The Involvement of Apoptosis in Chromosomal Rearrangement in Nasopharyngeal Carcinoma ( Collaborative Project with Dr. Sim Sai Ping @ Samirah Abdullah, Faculty of Medicine and Health Sciences University Malaysia Sarawak (UNIMAS) within the NPC Research Program (Khoo ASB) )

Nucleotide variation and gene expression studies of ribosomal protein genes in cases of nasopharyngeal carcinoma. ( Collaborative Project with Dr. Edmund Sim Ui Hang, Faculty of Resource, Science and Technology, University Malaysia Sarawak (UNIMAS) within the NPC Research Program (Khoo ASB) )

Nasopharyngeal Carcinoma: Roles of Epstein-Barr virus Latent Proteins in Invasion and Metastasis. ( Collaborative Project with Dr. Tan Eng Lai, International Medical University within the NPC Research Program (Khoo ASB)

Kisspeptins and GnRH as potential therapy for cancer (P.I. Dr. Alan Khoo, Institute for Medical Research, Co-principal investigator: Prof. Dr. Ishwar Parhar, Brain Research Institute, Monash University Sunway Campus) A collaborative project with Monash University Sunway Campus

Feasibility Study on Population-Based Colorectal Cancer Screening in Malaysia ( Noriah B, Roslan J, Selvinboss P, Koh CN, Zainudin MA, Amal NM, Khoo ASB, Tahir A, Roslinah A)

Year 2007

Establishment of model systems to study NPC and studies on the role of Epstein-Barr Virus (EBV) genes in NPC (Munirah A, Chu TL, Khairul MM Tan SK, Daker M, Roslina H, Kam PV, Hoe SLL, Nadiawati A, Siti Rohana P, Khoo ASB)

Nasopharyngeal specific genes and their promoters (Munirah A, Kam PV, Yee G, Chu TL and Khoo ASB)

Wnt signaling in Nasopharyngeal Carcinoma (NPC) (Munirah A, Chu TL, Daker M, Ngu W, Tan SK, Zabidi MM, Yap LF, Teo SH, Khoo ASB)

A multi institutional study on the Clinical Outcome of patients with nasopharyngeal carcinoma (NPC) (Pua KC, Khoo ASB, The Malaysian Nasopharyngeal Carcinoma Study Group)

Alterations of p53 and RB2/p130 genes in Malaysiannasopharyngeal carcinoma samples (Hoe SLL, ES Lee, Khoo ASB, SC Peh)

Study of antineoplastic activity and effects on gene expression in nasopharyngeal carcinoma(NPC) cell lines treated with microalgae extracts

(Lai PJ, Kok YY, Chu WL, Ling SN, Mariam S, Pauline B, Khoo ASB, Phang SM, Mak JW, Chu TL and Rakesh N)

Study of effects of metal complexes on cancer cells (Balraj P, Chu TL, Ng CH)

Feasibility Study on Population-Based Colorectal Cancer Screening in Malaysia ( Noriah B, Roslan J, Selvinboss P, Koh CN, Zainudin MA, Amal NM, Khoo ASB, Tahir A, Roslinah A)

Mutational studies on 21-hydroxylase deficient patients diagnosed with Congenital Adrenal Hyperplasia (CAH) (Lim PG, Pauline B, Huraizah S, Choy YS, Wu LL, Khoo ASB)

Year 2006

Phosphoinositide 3-kinase (P13K) and Wnt Signaling in Epithelial Cells (Munirah A, Susan H, Chu TL, Tan SK, Siti Rohana P and Khoo ASB)

Study Of Antineoplastic Activity and Effects On Gene Expression in Nasopharyngeal Carcinoma Cells Lines Treated with Micro algae Extracts. (Lai PJ. Kok YY, Chu WL, Ling SN, Mariam S, Pauline B, Phang SM, Mak JW, Chu TL, Rakesh N, Khoo ASB)

Alterations of p53 and RB2/130 Genes in Malaysian Nasopharyngeal (Hoe SLL, Lee ES, Khoo ASB, Peh SC)

Mutational Analysis in patients with 21-hydroxylase Deficiency in Congenital Adrenal Hyperplasia (Lim PG, Choy YS, Wu LL, Pauline B, Huraizah S, Khoo ASB)  

Application of Multiple Antigen Expression Techniques For The Study of Tumour Cell Lineage and Biological Properties. (Tan LP, Peh SC, Pauline B)

Study of Effects of Metal Complexes on Cancer Cells (Balraj P, Chu TL, Ng CH)

Year 2005

Molecular studies on disease biomarkers and pathogenesis of cancer: colorectal carcinoma as model ( Tan LP, Ng BK, Balraj P, Tan SK, Lim PKC )

Study of antineoplastic activity and cellular gene expression on nasopharyngeal carcinoma cell lines treated with microalgae extracts ( Lai PJ, Lim PKC, Ling SN, Chu WL, Mak JW )

Study of antineoplastic activity and cellular gene expression on nasopharyngeal carcinoma cell lines treated with microalgae extracts ( Lai PJ, Lim PKC, Ling SN, Chu WL, Mak JW )

Mutational Analysis of p53 and RB2/p130 Genes in Nasopharyngeal Carcinoma (NPC) ( Hoe LL, Sam CK )

PTEN mutational analysis in colorectal cancer tumours in Malaysia ( Balraj P, Siti R, Tan LP )

Year 2004

  Molecular studies on disease biomarkers and pathogenesis of cancer: colorectal carcinoma as a model ( Tan LP, Ng BK, Balraj P, Tan SK and Lim PKC )

  Study of Antineoplastic Activity and Cellular Gene Expression on Nasopharyngeal Carcinoma Cell Lines Treated with Microalgae Extracts ( Lai PJ, Lim PKC, Ling SN, Chu WL, Mak JW )

Year 2003

  Mutational analysis of the APC gene in Malaysian colorectal cancer patients (Balraj P, Lim PKC, Tan LP, Ng BK & Tan SK)

  Mechanism of action of antivirals against nasopharyngeal carcinoma at the molecular level (Lim PKC, Ling SN, Chu WL, Mak JW, Lai PJ, Tan BK & Ng BK)

Year 2002

  Mutational analysis of the APC gene (Balraj P, Lim PKC & Tan SK)

  Development of diagnostic test for Spinal Muscular Atrophy (SMA) (Balraj P, Siti Ruhana & Lim PKC)

Year 2001

  DNA vaccination of mice with Toxoplasma gondii P24 and mouse interleukin 12 genes (Lim PKC, Lee LN, Ng BK & Chong KH)

  B-cell epitope scanning of Toxocara canis recombinant fusion protein (Lim PKC & Ramlah M)

  Mutational analysis in-patients with tuberous sclerosis (Pauline B, Bock SY, Siti R & Harziah G)

  Analysis of xenobiotic enzyme gene polymorphisms associated with Hepatocellular Carcinoma (HCC) (Amyza S & Lim PKC)

Year 2000

  Cloning and expression of plasmepsin I from Plasmodium falciparum in yeast and bacterial systems (Lim PKC, Ng BK & Tan CS)

  Evaluation of different routes of DNA delivery using Toxoplasma gondii p 30 antigen as a model ( Lee LN , Lim PKC, Navaratnam V & Mak JW)

  Analysis of xenobiotic enzyme gene polymorphisms associated with Hepatocellular Carcinome (HCC) (Amyza MS, Navaratnam V, Lim PKC, Sharif MM & Lye MS)

  Anti-cancer screening of Eurycoma longifolia (Tongkat Ali) extracts using the MTT assay (Roslina H, Lim PKC, Tan SK & Chu TL)

  Establishment of Molecular Diagnostic Test for the Diagnosis of Angelman and Prader Willi Syndrome (Munirah A, Tan SK, Choy YS, Harziah G & Khoo ASB)

Year 1999

  Establishment of a mutation screening procedure for Factor IX gene mutations (Khoo ASB, Munirah A, Tan SK & Harziah G)

  The use of non-radioactive probe in molecular diagnostic testing of Prader-Willi/Angelman syndrome (Khoo ASB, Munirah A, Ee JN & Tan SK)

  Analysis of xenobiotic enzyme gene polymorphisms associated with Hepatocellular Carcinoma (HCC) (Amyza MS, Navaratnam V, Lim PKC, Sharif MM & Lye MS)

  Evaluation of DNA Vaccination for Toxoplasma gondii ( Lee LN , Lim PKC, Mak JW & Navaratnam V)

  Evaluation of three assay formats for the immunodiagnosis of human toxocariasis (Lim PKC, Yamasaki H et al )

  Establishment of the MTT assay for screening of potential anti-cancer agents (Roslina H, Lim PKC, Tan SK & Chu TL)

Year 1998

  Production and characterization of Plasmodium falciparum -specific monoclonal antibodies (Lim PKC, Radzan T & Amyza S)

  Development of a recombinant fusion protein based-dot blot assay for the immunodiagnosis of human toxocariasis (Lim PKC, Tan SK, Yamasaki H, Ngah Z, Hanisah S & Ramlah M)

  Development of recombinant Toxoplasma gondii antigens for diagnosis and vaccines (Lim PKC & Ng BK)

  Evaluation of DNA vaccination for Toxoplasma gondii (Khoo ASB, Lee LN & Lim PKC)

  Breast cancer study (Khoo ASB, Balraj P et al )

  Mutation analysis of the ornithine transcarbamylase (OTC) gene and prediction of the effects of the mutation by molecular modeling ((Khoo ASB, Balraj P, Rachedi A, Chin CN & Volpi L)

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