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With the reorganisation of the IMR, the Cancer Research Centre (CaRC) was established on 16 th April 2001 . The CaRC has three Units consisting of the Haematology Unit, Molecular Pathology Unit and the Stomatology Unit.
Cancer intervention
• Advanced molecular cytogenetics for diagnosis and prognostication in leukaemia
• Real time PCR for monitoring treatment and detection of minimal residual disease in leukaemia
• Molecular detection for multiple infections of Human Papilloma Virus (able to detect HPV 16 and HPV 18 in a single test)
• Use of specific mutation pre-symptomatic test for detecting familial adenomatous polyposis coli (Restriction Enzyme assay to confirm presence of mutant sequence)
• identification of new diagnostic markers
- eg. colorectal cancer and leukemia
• Pre-symptomatic screening for patients at risk of developing colorectal cancer
• Screening for gene aberrations in Leukemia using molecular methods
• Develop strategies for early detection and evaluation of diagnostic modalities for oral cancer
• In vitro screening of microalgae extracts to identify new anti-proliferative/anti-viral compounds for nasopharyngeal carcinoma mechanism of action of potential compounds on cancer or viral genes
• In vitro screening of natural active compound for anti- proliferative properties from Hibiscus rosa sinensis
• Cancer biology:
- To study the mechanisms involved in tumour progression and metastasis
• Cancer intervention:
- Gene expression profiling for molecular classification / prognostication in acute leukaemia and breast cancer
• Cancer immunology:
- To study the role of biomolecules involved in cancer immunology to gain a better understanding of cancer development and progression …… for better management
The objectives of the CaRC are to: conduct research in cancers that are of local importance; improve assessment of prognosis of cancers by molecular characteristics analysis; provide better assessment of individual patient response to treatment; improve cure rate, quality of life and prevent occurrence of secondary malignancy; and study the aetiology and control of cancer through its surveillance, education, research and service activities.
