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Pengenalan
Imunogenetik adalah kajian mengenai hubungan di antara genetik dan sistem imun. Kedua-dua sistem ini merupakan sistem yang kompleks serta canggih dan interaksi di antara keduanya menimbulkan beberapa persoalan kajian yang mencabar. Unit Imunogenetik menjalankan penyelidikan dan menyediakan perkhidmatan diagnostik khusus untuk program transplan di seluruh negara melalui penjenisan tisu HLA. Makmal ini ditubuhkan pada tahun 1985 dan memberi khidmat sokongan bagi kedua-dua jenis tranplan iaitu sum-sum tulang dan organ. Penjenisan tisu HLA yang bukan bertujuan untuk pemindahan turut disediakan seperti kajian berkaitan dengan penyakit (disease association studies). Kesemua penjenisan tisu HLA dilakukan menggunakan teknik molekular. Unit Immunogenetik juga menyelia dan bekerjasama rapat dengan Malaysian Marrow Donor Registry (MMDR) yang kini bertukar nama kepada Malaysian Stem Cell Registry Malaysia (MSCR). Bagi penderma MSCR, kami menguji kedua-dua jenis penderma iaitu yang mempunyai pertalian darah dan yang tidak serta transplan dari darah tali pusat. Unit Immunogenetik terlibat dalam menyediakan latihan untuk petugas profesional kesihatan yang terlibat dalam bidang transplan.
Objektif/ Teras Penyelidikan
Unit Immunogenetik menyediakan:
- Perkhidmatan ujian sebelum transplan bagi sum-sum tulang dan organ untuk pengesahan keserasian.
- Perkhidmatan ujian selepas transplan bagi organ.
- Ujian bagi pesakit yang akan keluar negara ataupun adik-beradik bagi pesakit yang berada di luar negara.
- Ujian untuk penyakit yang berkaitrapat dengan alel HLA serta memberikan kesan buruk ke atas pesakit.Our research focuses on disease associations and population genetics.
Penyelidikan yang dijalankan memberi tumpuan kepada bidang genetik yang berhubungkait dengan penyakit-penyakit dan genetik populasi.
Kami mengenalpasti dan menentukan frekuensi alel dalam penduduk tempatan serta yang berhubungkait dengan penyakit seperti 'aplastic anemia', 'rheumatoid arthritis' dan 'ankylosing spondylitis'.
Perkhidmatan
- Penjenisan tisu HLA Kelas I
- Penjenisan tisu HLA Kelas II
- HLA-B*27, -B*5, -B*12, -B*1502, -B*5701
- HLA Crossmatch
- Ujian antibodi HLA- saringan kelas I
- Ujian antibodi HLA- saringan kelas II
- Pengesanan antibodi HLA-antibodi spesifik
Senarai kakitangan
Information on testing may be obtained by contacting:
- Puan Maiselamah Lisut
- Puan Lee Yin Yin
- Puan Rozinah Mohamed
Pembentangan & Penerbitan AIRC Tahun 2011
|
Bil |
Title |
|---|---|
|
1 |
Zailatul Hani Mohamad Yadzir, Rosmilah Misnan, Noormalin Abdullah, Masita Arip, Shahnaz Murad Identification of Major Allergens of Wildflower Honey. (2011) Southeast Asian Journal of Tropical Medicine and Public Health 42(2): 370-75 |
|
2
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Choong-Chor Chang, Chun-Lai Too, Shahnaz Murad, and Suraiya Hani Hussein Association of HLA-B*1502 allele with carbamazepine induced toxic epidermal necrolysis and Stevens–Johnson syndrome in the multi-ethnic Malaysian population. 2011. International Journal of Dermatology, 50, 221–224 |
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3 |
Too Chun-Lai, Leonid Padyukov, Jasbir Singh Dhaliwal, Emeli Lundstrom, Abqariyah Yahya, Nor Asiah Muhamad, Lars Klareskog, Lars Alfredsson, Per Tobias Larsson, Shahnaz Murad, for the Malaysian epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Study Group Shared Epitope Alleles Remain A Risk Factor for Anti-Citrullinated Proteins Antibody (ACPA) – Positive Rheumatoid Arthritis in Three Asian Ethnic Groups PLOS One June 2011 Volume 6 Issue 6 e21069 |
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4 |
JS Dhaliwal, M Shahnaz, A Azrena, Irda YA, Salawati M, CL Too, and Lee YY Gene frequencies of HLA-A, -B and –DR alleles in 3 indigenous populations of Sabah and Sarawak. Tissue Antigens 75:166-169(2011) |
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5 |
Adiratna Mat Ripen1,2, Takeshi Nitta1, Shigeo Murata3, Keiji Tanaka4, Yousuke Takahama1,*Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t. European Journal of Immunology 411, 278–1287, May 2011 |
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6 |
JS Dhaliwal, Lily Wong, Muhammad Amir Kamaluddin, Lee Yin Yin and Shahnaz Murad. Susceptibility to Aplastic Anaemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia. Human Immunology (in press) 2011 |
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7 |
Uma Devi Palanisamy, Muniswaran Sivanathan, Ammu Kutty Radhakrishnan, Nagaraja Haleagrahara, Thavamanithevi Subramaniam and Gan Seng Chiew. An Effective Ostrich Oil Bleaching Technique Using Peroxide Value as an Indicator. Molecules 2011, 16, 5709-5719 |
Presentations 2011
|
Bil |
Title |
Presenter |
Date & Venue |
|---|---|---|---|
|
1. |
Identification of the Major Allergens of Macrobrachium rosenbergii (Giant Freshwater Prawn) by Two-Dimensional Electrophoresis and Mass Spectrometry |
Zailatul Hani Mohamad Yadzir |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
2. |
Detection of autoantibodies (anti-gliadin, anti-tissue transglutaminase and anti-endomysium) in diagnosis of celiac disease- A preliminary report. |
Dr Ainur Yusniza Yusof |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
3. |
Detection of Antiphospholipid Antibodies In Female With Fetal Loss |
Ching Yee Ming |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
4. |
High Resolution DNA Typing of HLA-A, -B & -DRB1 Loci by PCR-SSOP-Luminex in Malay Population |
Norfarhana Khairul Fahmy |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
5. |
Detection of Neuronal Autoantibodies (Anti-Hu, Anti-Ri, Anti-Yo, Anti-Ma and Anti-Amphiphysin) in patients with Paraneoplastic Neurological Syndrome (PNS) |
Dr Masita Arip |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
6. |
Allergy to Paracetamol: Two Cases of Successful Rapid Desensitization with Paracetamol |
Dr. Noormalin Abdullah |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
7 |
A Retrospective Study of Frequency of Autoantibodies (Anti -Islet Cells (ICA), Anti-Glutamic Acid Decarboxylase (GAD), Insulin Autoantibodies (IAA) and Anti-Tyrosine Phosphatase (IA2) ) In Type 1 Diabetes |
Dr Norhazlin Mustafa |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
8 |
Defining B cell defects in Primary Immunodeficiency patients in Malaysia (Tajuk pembentangan lisan: Analysis of Bruton’s Tyrosine Kinase (BTK) expression in Monocytes by Flow Cytometry) |
Chear Chai Teng |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
9 |
Wiskott-Aldrich protein expression in a child with X linked thrombocytopenia |
Dr Gill HK |
11-13th March 2011, 12th Malaysian Congress and Exhibition on Allergy and Immunogy, Sheraton Imperial Kuala Lumpur |
|
10 |
“Identification Of Bruton’s Tyrosine Kinase Gene (Btk) Mutation In A Malaysian Family with X-Linked Agammaglobulinemia” |
Chear CT |
9 - 10 June 2011, Armada Hotel, Petaling Jaya Rare Disorder & Genetics Conference 2011 |
|
11 |
Evaluation of Saliva As A Source of DNA for Human Leukocyte Antigen (HLA) – A Pilot Study |
Dr Masita Arip |
18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi 10th Annual Scientific Meeting, College of Pathologists AMM |
|
12 |
Distribution of HLA-A, -B & -DRB1 Alleles Among the Malay Population in Malaysian Marrow Donor Registry (MMDR) |
Norfarhana Khairul Fahmy |
18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi 10th Annual Scientific Meeting, College of Pathologists AMM |
|
13 |
HLA-A, -B & -DR Alleles Frequencies in Chinese Population: A Malaysian Marrow Donor Registry Experience |
Dr Norhazlin Mustafa |
18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi 10th Annual Scientific Meeting, College of Pathologists AMM |
|
14 |
HLA-A, -B and –DR Alleles and frequencies among Indians in Malaysian Marrow Donor Registry |
Salawati Mansor |
18 – 19 June 2011, Meritus Pelangi Beach Resort, Langkawi 10th Annual Scientific Meeting, College of Pathologists AMM |
Soalan Lazim (item berkemungkinan untuk dimasukkan)
- Apakah HLA?
- Mengapa pesakit perlu menjalani ujian HLA?
- Bagaimanakah Jenis HLA seseorang ditentukan?
- Bagaimana HLA menaip dijalankan?
- Apakah antibodi?
- Apakah silang padan?
- Apakah PRA?
- Apa yang menyebabkan antibodi anti-HLA berkembang?
- Bolehkah anti-HLA antibodi berubah?
- Mengapa ia boleh jadi sukar untuk mencari penderma HLA-dipadankan?
- Apakah Immunogenetik?
