Unlimited applications in:
cancer,
cardiac diseases,
diabetes,
immunology and allergic responses,
toxicology,
pharmacology
disease pathogenesis
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IMR will acquire the various technologies for proteome research through training and technology transfer activities
Funstional Genomics and Proteomics will lead to:
• New diagnostic and prognostic markers of diseases
• Better understanding of diseases for improved disease management/ treatment strategies
• Identification of new genes associated with diseases
• New targets for vaccine or drug development
• Development of new technologies (patents)
Therefore, there is need to acquire expertise and facilities for new technologies in functional genomics and proteomics. The platform technologies are 2D gel electrophoresis, bioinformatics, microarray, nanotechnology, biosensor
and etc.
MICROARRAY TECHNOLOGY
Fairly complete analysis of all genes that change in a disease state, will provide new targets for the development of potential diagnostics and therapeutics
eg. Gene expression
in colorectal cancer.
Potential applications of microarray technology are:
• identification/detection of genes of complex genetic diseases
• drug discovery and toxicology studies
• mutation/polymorphism detection
• to study host-pathogen interactions
• differential expression of genes in different tissues or disease states
IMPROVED MOLECULAR DIAGNOSTICS
Genetic tests which allow assessment of
a genetic risk:
Blood diseases
Cancers
CVD risk
Metabolic disorders
Muscle disease
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Useful for Prenatal genetic counselling
Family risk assessment
Improved diagnosis and patient
management
VECTORS STUDIES |
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• Molecular basis of vectorial
resistance to parasites or
viruses
• Engineering of mosquitoes resistant
to disease transmission
• Genetic manipulation to alter
host-finding behaviour
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CANCER RESEARCH
• New biomarkers for early diagnosis, prognosis
• Study the role of biomolecules in tumour progression, tumour immunology to understand cancer better
• Identification of new genes (targets) for drug development
TRADITIONAL AND COMPLEMENTARY MEDICINE RESEARCH
New technologies such as:
High throughput screening,
Combinatorial chemistry,
Metabolomics (study of small molecular components in a cell,
Bioinformatics
will be harnessed to spearhead the drug discovery programme leading to the identification and synthesis of new herbal compounds for a wide range of diseases.
Link with NINPV in this area of research.
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PHARMACOGENOMICS
How an individual's genetic inheritance affects the body's response to drugs
Genomic profiling of patients and their responses to different drugs will lead to improved treatment and management:
• personalized drugs
• more targeted therapy for specific diseases
eg. Cancer
• appropriate drug dosage will decrease damage to nearby healthy cells
• decrease number of adverse drug reactions
VACCINE RESEARCH
With the establishment of NINPV in Biovalley Malaysia, vaccine research will become a focused research area
with tremendous commercial potential.
Biotechnological tools will be used to identify vaccine candidates for important diseases and relevant expertise and technologies will be acquired for the development and production of important vaccines.
GENE THERAPY
To correct defective genes responsible for disease development eg. Cancer genes
